This match is a toss-up in my eyes, as Wawrinka does have the edge on clay and is playing better tennis overall, but it's tough to bet against Murray and that defense.
"It's never fun to lose a match, but I took a great experience from this match to play on the center court", he said.
In windy conditions Murray double-faulted to lose serve in the third game and Nishikori pinged a forehand victor past him to move 5-2 ahead before serving out the set.
Murray was the stronger player throughout this one, and the struggles he suffered in the buildup to this Grand Slam showdown now feel a long time ago, as he notched a 6-3, 6-4, 6-4 win.
Halep, who was runner-up at Roland Garros in 2014, will next face second-seeded Karolina Pliskova.
The 32-year-old is the oldest man to make the last four at Roland Garros since Jimmy Connors in 1985.
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Murray was just the steadier, although he also played some poor games, dropping serve twice in the third set - both times immediately after breaking Nishikori - and once to start the fourth.
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In the women's category, Halep defeated 21st-seeded C. Suarez Navarro of Spain 6-1, 6-1 and Garcia defeated fellow compatriot Alize Cornet 6-2, 6-4 in an all-French affair again on Philippe-Chatrier.
The third-seeded Halep, who trailed 5-0 in the first set, was down 5-1 in the second.
"It's not like I played a great point the next point".
"I think if someone is intentionally slowing a match down they should be punished for that, but it's a rule that is going to be challenging regardless of whether there is a clock on the court or not", added Murray.
"I came in playing garbage. Once I started to get into a rhythm I was able to keep him a bit further away from the baseline and that made a big difference". But, yeah, a little bit gained some confidence during second and third. "He [Nishikori] was dictating all of the points in the first set".
"You have Ivan Lendl in your team, the guy has so much experience".
The three-time Grand Slam champion dropped the first set before prevailing 2-6, 6-1, 7-6 (7-0), 6-1.
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