January 20, 2018

Study reveals how alcohol damages DNA, raises cancer risk

05 January 2018, 02:31 | Rodolfo Wallace

Study reveals how alcohol damages DNA, raises cancer risk

Alcohol consumption increases cancer risk by triggering DNA damage

Drinking alcohol doesn't just damage the liver and kidneys - turns out it could increase cancer risks and damage DNA as well.

Our previous research revealed the principle mechanism that protects us from alcohol-induced DNA damage.

ALCOHOL can give some people more than simply a hangover, according to new research that shows how it damages DNA in stem cells, thereby increasing the risk of cancer.

The recent work showed that acetaldehyde slices through DNA, causing permanent damage, if the effects of the toxin are not neutralized by two natural defense mechanism.

The team got the mice drunk with diluted alcohol, or ethanol, then used chromosome analysis and DNA sequencing to gauge the genetic damage.

Beer, wine and spirits can irreversibly damage the body's reserve of stem cells, and eventually lead to deadly mutations of their DNA. Bits of DNA were deleted, bits were broken and we even saw parts of chromosomes being moved about and rearranged. In addition, the new insight into the function of p53 in blood stem cells may explain why certain blood cancers become resistant to chemotherapy.

Paladins is the Latest Game to Rip Off PUBG
A major variation is that Paladins champions have class abilities and, in Paladins : Battlegrounds , players will have mounts. Heroes will be able to hop onto their mounts and start exploring the map, looting all sorts of gear to take on other players.

Durant leads NBA All-Star vote, Curry first among guards
Granted, he'll still need help to lock up a spot among starters from the Eastern Conference before voting ends on January 16. Those captains then will make picks from the reserve pool, which is selected by National Basketball Association coaches.

LG packs its first ever 4K projector for CES 2018
The company wants to tap the growing user base under the Home entertainment systems market for compact and affordable projectors. While they are "heavy, expensive, and hard to install", according to the company, the HU80KA is the opposite of all these.

"How exactly alcohol causes damage to us is controversial", study coauthor Ketan Patel of the Medical Research Council Laboratory of Molecular Biology tells The Guardian. Most life on Earth, from bacteria to mammals, also possess this protective mechanism, but, unlike humans, they have not yet developed the capacity to manufacture alcohol on an industrial scale for consumption. There are seven common cancers that have been confidently linked to alcohol: mouth, upper throat, laryngeal, oesophageal, breast, liver, and bowel. Translating these results to humans means that, for some people, drinking alcohol could be exponentially more risky depending on their individual ability to process acetaldehyde. The scientists examine the genetic damage caused by this harmful chemical.

They found that ALDH2-deficient mice had four times the cell damage as control mice with normal ALDH2 production.

When the body breaks down alcohol, it briefly converts it into a chemical called acetaldehyde For most people, acetaldehyde is only a temporary by-product of alcohol, before it is oxidized by the enzyme aldehyde dehydrogenase 2 (ALDH2). However, there weren't many studies that explained the process leading to the growth of these cells.

In particular, the scientists found that acetaldehyde, an endogenous and alcohol-derived metabolite, can break and damage DNA within blood stem cells. Millions of people worldwide either lack or carry faulty versions of these enzymes.

"We know that alcohol contributes to over 12,000 cancer cases in the United Kingdom each year, so it's a good idea to think about cutting down on the amount you drink", Professor Linda added. "But it's important to remember that alcohol clearance and DNA fix systems are not flawless and alcohol can still cause cancer in different ways, even in people whose defence mechanisms are intact".

"Alcohol contributes to over 12,000 cancer cases in the UK each year", says Professor Linda Bauld, Cancer Research UK's expert on cancer prevention.

Other News

Trending Now

USA 'looking for reasons' to pressure Iran: Russia
Mr Trump's administration has denied having any hand in the demonstrations, saying they arose completely spontaneously. Russian Foreign Ministry spokeswoman Maria Zakharova went on to mock the US call for a United Nations discussion.

Serena Williams Withdraws from Australian Open Due to Fitness Concerns
She added: "The memory of last year's Open is one that I will carry with me, and Olympia and I look forward to coming back again". The 2018 Australian Open will begin on January 15.

United States suspending military equipment delivery, most aid to Pakistan
In August, he was more forthright and warned that Pakistan "has much to lose" if ig persisted in aiding terrorists. He reiterated longstanding allegations that Pakistan gives "safe haven to the terrorists we hunt in Afghanistan".

Galaxy S9 Could Steal iPhone X's Biggest Feature
The imaging sub-system enables advanced stabilisation and real-time out-of-focus photography in high-resolution image and video. As for graphics, Samsung has opted for ARM's Mali G72 GPU, being the same hardware seen in Huawei 's Kirin 970 chip.

Honours even as the Hammers hinder Spurs' top-four aspirations
After a crucial win against West Brom on Tuesday, this point takes West Ham two points clear of the drop zone. I said to myself to try something different, so I did and it went in.

World Health Organization Lists Two Gaming-Related Health Disorders
Having captivated gamers for more than four decades, more than two billion people around the world enjoy video games. And those new ones start to make the original one worse and it all becomes a "jumbled mess".

4 dead as care facilities in BC's Interior deal with flu outbreaks
Due to a report out of Australia, some news agencies are saying that this season's flu vaccine is only 10 percent effective. In cases of those with flu-like symptoms, the department says they have over 10,000 unconfirmed cases.

What Is Thundersnow? Winter Storm Grayson Causes Rare Weather Phenomenon
Highs in the single digits and teens will rewrite the record book for Jan 5th and 6th", Maue wrote in a tweet on January 3. However, if the storm heads east and out into seas, the amount of snow will decrease and wind speeds will die down.

Joe Thornton has chunk ripped out magnificent beard in brawl
For his part, Kadri said that he didn't intend to grab Thornton's beard, noting that he's "a hockey player, not a barber". Specifically, it ended up in the catching glove of backup goalie Aaron Dell , who showed it off to teammates.

Roy Moore accuser Leigh Corfman files defamation lawsuit against Moore, campaign
Moore's comments about Corfman were defamatory, she claims in the suit, filed today in Montgomery County, Ala., the Post reports. Corfman after the election and the content of his affidavit demonstrate that if not enjoined, he will continue to defame Ms.