giftedviz.com
giftedviz.com May 27, 2018


Study reveals how alcohol damages DNA, raises cancer risk

05 January 2018, 02:31 | Rodolfo Wallace

Study reveals how alcohol damages DNA, raises cancer risk

Alcohol consumption increases cancer risk by triggering DNA damage

Drinking alcohol doesn't just damage the liver and kidneys - turns out it could increase cancer risks and damage DNA as well.

Our previous research revealed the principle mechanism that protects us from alcohol-induced DNA damage.

ALCOHOL can give some people more than simply a hangover, according to new research that shows how it damages DNA in stem cells, thereby increasing the risk of cancer.

The recent work showed that acetaldehyde slices through DNA, causing permanent damage, if the effects of the toxin are not neutralized by two natural defense mechanism.

The team got the mice drunk with diluted alcohol, or ethanol, then used chromosome analysis and DNA sequencing to gauge the genetic damage.

Beer, wine and spirits can irreversibly damage the body's reserve of stem cells, and eventually lead to deadly mutations of their DNA. Bits of DNA were deleted, bits were broken and we even saw parts of chromosomes being moved about and rearranged. In addition, the new insight into the function of p53 in blood stem cells may explain why certain blood cancers become resistant to chemotherapy.

OR politicians push back against federal pot enforcement
Earl Blumenauer, an Oregon Democrat and co-chairman of the Congressional Cannabis Caucus, called Sessions' decision "outrageous". Washington state Attorney General Bob Ferguson said in a statement he was "disappointed and troubled" by Sessions's decision.


Another Monster Hunter World Beta Coming To PS4 On January 19
The good news here is that the delays are not so bad as Monster Hunter World is still coming out 2018. A third Monster Hunter World beta was confirmed during Capcom's Winter Live Stream this week.


Ajit Pai Death Threats Keep FEC Head From Electronics Show
But Pai canceled his appearance , according to the Consumer Technology Association (CTA), which runs the CES conference. "We look forward to our next opportunity to host a technology policy discussion with him before a public audience".


"How exactly alcohol causes damage to us is controversial", study coauthor Ketan Patel of the Medical Research Council Laboratory of Molecular Biology tells The Guardian. Most life on Earth, from bacteria to mammals, also possess this protective mechanism, but, unlike humans, they have not yet developed the capacity to manufacture alcohol on an industrial scale for consumption. There are seven common cancers that have been confidently linked to alcohol: mouth, upper throat, laryngeal, oesophageal, breast, liver, and bowel. Translating these results to humans means that, for some people, drinking alcohol could be exponentially more risky depending on their individual ability to process acetaldehyde. The scientists examine the genetic damage caused by this harmful chemical.

They found that ALDH2-deficient mice had four times the cell damage as control mice with normal ALDH2 production.

When the body breaks down alcohol, it briefly converts it into a chemical called acetaldehyde For most people, acetaldehyde is only a temporary by-product of alcohol, before it is oxidized by the enzyme aldehyde dehydrogenase 2 (ALDH2). However, there weren't many studies that explained the process leading to the growth of these cells.

In particular, the scientists found that acetaldehyde, an endogenous and alcohol-derived metabolite, can break and damage DNA within blood stem cells. Millions of people worldwide either lack or carry faulty versions of these enzymes.

"We know that alcohol contributes to over 12,000 cancer cases in the United Kingdom each year, so it's a good idea to think about cutting down on the amount you drink", Professor Linda added. "But it's important to remember that alcohol clearance and DNA fix systems are not flawless and alcohol can still cause cancer in different ways, even in people whose defence mechanisms are intact".

"Alcohol contributes to over 12,000 cancer cases in the UK each year", says Professor Linda Bauld, Cancer Research UK's expert on cancer prevention.



Other News

Trending Now

All Macs, iPhones, iPads exposed to chip flaw
Apple says it as of now discharged "alleviations" in iOS 11.2, macOS 10.13.2, and tvOS 11.2 to help safeguard against Meltdown . Apple this evening has officially released a statement on the Meltdown and Spectre bugs affecting ARM and Intel processors.

Logan Paul Announces Break From YouTube Amid Fallout From Dead Body Video
Furthermore, Paul has turned to social media to announce that he will not be posting any new videos in the near future. He shared a tearful video the following day, describing the stunt as a "severe and continuous lapse in judgement".

Chelsea boss Conte backs Morata after blunt show
The 28-year-old spoke of his frustration at being a bit-part player after he scored twice in the win against West Brom this week . Analysis after the match showed that no player has missed more in a Premier League match this season.

Traded to White Sox
Avilan held left-handed hitters to a.195 batting average, so Avilan will likely also be the White Sox situational lefty. Soria's 3.70 ERA last season doesn't jump off the page, but his 2.23 FIP suggests that he may have been a bit unlucky.

Ryan Shazier's Dad Says His Son Has Regained Feeling In His Legs
In the weeks since his injury, he has been watching the Steelers' games from a suite at Heinz Field. His fiancée accompanied him during the visit to the team's practice facility in a wheelchair.

4 dead as care facilities in BC's Interior deal with flu outbreaks
Due to a report out of Australia, some news agencies are saying that this season's flu vaccine is only 10 percent effective. In cases of those with flu-like symptoms, the department says they have over 10,000 unconfirmed cases.

Joe Thornton has chunk ripped out magnificent beard in brawl
For his part, Kadri said that he didn't intend to grab Thornton's beard, noting that he's "a hockey player, not a barber". Specifically, it ended up in the catching glove of backup goalie Aaron Dell , who showed it off to teammates.

Mega Millions Powerball Jackpot Exceeds $418 Million
Because there was no victor in the Mega Million lottery drawing on Tuesday that pot has grown to $445 million. Saturday's $550 million Powerball jackpot is now the 8th largest in U.S history.

Romaine lettuce may be source of E. coli outbreak
Rogers said it's best to assume that any romaine lettuce may be contaminated, even if it's sold in bags and packages. Total E. coli outbreaks in the USA are at 17 since the end of November.

Caitlyn Jenner calls out Piers Morgan for transphobia
I had 23 years of raising her. "You don't make a joke about that because it's not amusing , it's life", Jenner said. Caitlyn replied: "Except for the last few pages when I talked about gender confirmation".