March 23, 2018

Men who take ibuprofen are at risk for fertility problems, study says

10 January 2018, 01:22 | Rodolfo Wallace

Men who take ibuprofen are at risk for fertility problems, study says

Men who take ibuprofen are at risk for fertility problems, study says

However, despite the change in LH levels, the men's testosterone levels didn't change. Luckily, in the test subjects the condition was mild, but the researchers said people should be concerned if they use anti-inflammatory drugs regularly over long periods of time.

Common brands of ibuprofen include Advil and Motrin.

Bernard Jégou, a senior author on the study at the French National Institute of Health and Medical Research, said that he believes that there is no problem in people taking ibuprofen to alleviate pain in the short term but he warns against taking the drug for months on end if it was not absolutely necessary. A control group of 17 men took a placebo instead.

Those who took the ibuprofen were more likely to have indications of testicular problems - including a condition called compensated hypogonadism that affects reproductive health - meaning men are less likely to be able to father a child.

Results showed that ibuprofen use led to an elevation of luteinizing hormone (LH) and a decreased testosterone/LH ratio, which is routinely used as a marker of testicular Leydig cell function. According to a recent study, however, regular consumption of the drug could lead to several side-effects, including male sterility. "This study should give pause for thought to sportsmen using them routinely for exercise-induced aches and pains". "Taken together, these in vivo data suggest that ibuprofen induced a state of compensated hypogonadism during the trial..." the study states.

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"However, this is now speculative". With regard to long-term ibuprofen use, "It is also of concern that men with compensated hypogonadism may eventually progress to overt primary hypogonadism".

Ibuprofen is a very common over-the-counter pain reliever that we've probably all taken at some point. "However, it is recommended that if men (or women) need to take it for more than 3 days consecutively then they should first consult their family doctor".

However, for men, it could compromise their ability to procreate, a new study suggests.

Even though this was a small study and further research is needed, the findings are important because ibuprofen is one of the most widely-used medications, Erma Drobnis, an associate professional practice professor of reproductive medicine and fertility at the University of Missouri, Columbia, told CNN.

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