"These are tough conditions to move around in, so if you don't need to be on the road. you shouldn't", said New York Mayor Bill de Blasio on Twitter.
So far, a state of emergency has been declared for the states of Georgia, North Carolina, Virginia, and Florida.
Late on Wednesday night, a baggage vehicle and two sleeper cars on an Amtrak train travelling from Miami to NY, with 311 passengers onboard, derailed as it was slowly backing into a station in Savannah, Georgia.
Storm intensity is measured by central pressure - the lower the pressure, the stronger.
This morning's #GOESEast view of the powerful #BombCyclone as it batters the East Coast with heavy snow and strong winds.
"In this case, with a nor'easter, the cold air from Canada combined with the warmer ocean waters of the Gulf Stream is what will trigger this explosive strengthening pattern", Dean said.
The effects of it resemble a hurricane due to the high winds it creates, only there will be much colder temperatures.
This storm has been dubbed a "bombcyclone" or "bombogenesis" by meteorologists as it is expected to rapidly intensify. Wind chills will be brutal this weekend, with some areas in the Northeast feeling like it is 40 below zero.
Bomb cyclones occur when dry air in the stratosphere, the second-closest atmospheric layer to the Earth's surface, flows to an area of low pressure to try and equalise the differences in pressure.
Number of flu-related pediatric deaths rises to 20 — CDC
Balter said while this year's outbreak was early, it's too soon to say what exactly caused the spike in the number of illnesses. Heartbreaking stories have been circulating in the media this week about children and young adults dying from the flu.