Chicago O'Hare travelers possibly exposed to measles
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Giants Expected To Hire Shurmur As Next Head Coach
Sean Penn says Trump is 'enemy of mankind'
Might £7bn supply immediate GKN to separate in two?
Breast cancer gene not linked to higher risk of death
14 January 2018, 12:30 | Rodolfo Wallace
It is hoped the research will help women to decide on treatment
Dave Fredrickson, Executive Vice President, Head of the Oncology Business Unit, AstraZeneca, said, "This new approval for Lynparza makes it the first and only PARP inhibitor approved in metastatic breast cancer, and the only PARP inhibitor approved beyond ovarian cancer". "This approval demonstrates the current paradigm of developing drugs that target the underlying genetic causes of cancer, often across cancer types". "This is significant for breast cancer patients, as the identification of the BRCA status, in addition to hormone receptor and HER2 status, becomes a potentially critical step in the management of their disease".
The study involved 2,733 British women from 127 hospitals, who had been diagnosed with the condition at the age of 40 or below. Twelve percent of the women had a BRCA mutation.
The BRCA1 and BRCA2 genes usually produce molecules inside cells that help to fix DNA.
On Thursday, research led by the University of Southampton concluded that BRCA-mutated breast cancer is no more unsafe or aggressive than any other form of the disease.
Survival rates after two years were 97 percent for women with a BRCA mutation and 96.6 percent for those without the mutation, the findings showed. In the trial, olaparib significantly prolonged progression-free survival (PFS) compared with chemotherapy, and reduced the risk of disease progression or death by 42% (hazard ratio [HR], 0.58; 95% confidence interval [CI], 0.43-0.80; P = 0.0009).
The most common adverse reactions of patients who received olaparib included: nausea, anemia, fatigue, vomiting, neutropenia, respiratory tract infection, leukopenia, diarrhea, and headache.
Saudi Arabia claims to intercept Houthi-fired missile
The rebel-run news agency Saba gave the same toll and accused the coalition of using cluster bombs in that attack in Kataf city. On Dec. 19, 2017, the Houthi movement fired a ballistic missile toward the royal palace in the Saudi capital of Riyadh.
Steelers WR expected to play Sunday despite illness
Brown set an National Football League record with 100-plus receptions in five consecutive seasons, including 101 this season. Brown returned to practice on Monday after suffering a calf injury against the New England Patriots in Week 15.
China's trade surplus with United States up 13 percent
Huang Songping, a commerce ministry spokesman, said the numbers reflect the "mild recovery of the world economy a year ago ". Analysts at Nomura say continued global growth may offer support, while possible USA protectionism could weigh on exports.
Severe side effects occurred in 37 percent of Lynparza patients, compared to 51 percent of those on standard therapy.
These are offered to women with faulty genes to cut their risk of developing cancer.
Its U.S. marketing application for same indication as ZEJULA is now under FDA review with an action date of April 6.
This is the third indication approved for Lynparza in the United States, where it has been used to treat almost 4,000 advanced ovarian cancer patients.
Lynparza has been a key part of AstraZeneca CEO Pascal Soriot's case that oncology represents a big growth opportunity - badly needed after generics chewed up market niches worth billions.
The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The approval of the BRACAnalysis CDx was granted to Myriad Genetic Laboratories, Inc. The agency also is responsible for the safety and security of our nation's food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products.
Tunisia arrests 237 in clashes, dozens hurt
Tunisia is widely seen as the sole democratic success story of the 2010-11 Arab Spring uprisings. Police have insisted they did not kill the man and said he suffered from "respiratory problems".
LG has made a 65-inch rollable OLED display
At CES 2018 LG will also showcase a brand new 88-inch 8K OLED display that will definitely impress even the most critical people. The 65-inch UHD rollable LG OLED display the company chose to amaze us with will be showcased at CES 2018 this week.
Relations with North Korean leader 'very good,' Trump says
Trump also told Moon that Vice President Mike Pence would lead the USA delegation to the Olympic Games, the White House said. The paper reported that Trump did not give any inkling if the two bitter rivals have had established any contacts as of yet.
Need to revamp education system in Kashmir: Gen Rawat
We are prepared to handle", the Army Chief said while assuring that the security forces are manning the border continuously. Gen Rawat said, "We understand China is a powerful country but we are not a weak nation".