giftedviz.com
giftedviz.com December 13, 2018


Experts push to reclassify diabetes types

04 March 2018, 01:56 | Rodolfo Wallace

Emma Ahlqvist PhD

Emma Ahlqvist PhD Associate Professor Lund University

The researchers studied 14,775 patients across Sweden and Finland, analysing their genes and comparing disease progression, treatment and development of complications for each type.

Currently, the medical community broadly recognizes two types of diabetes, which is a disease that impairs the body's ability to properly produce or regulate blood sugar.

Cluster 1 describes diabetes similar to Type 1 diabetes wherein it is an autoimmune disease that affects young seemingly healthy people who can not produce insulin. Clusters 3 and 4 can be thought of as falling between the two extremes.

The study was just on Scandinavians and the risk of diabetes shifts extensively around the globe, for example, the expanded risk in South Asians.

Cluster 3: Severe insulin resistant diabetes, affecting 15.3 per cent of patients studied.

Other researchers caution that the team's results need to be replicated elsewhere, using even more diverse patient samples.

Where did the story come from?

The team, from Lund University and the Institute for Molecular Medicine in Helsinki, examined data from 14,625 patients in five cohorts between January 2008 and November 2016.

The researchers subsequently repeated the analysis in a further three studies from Sweden and Finland.

The results have been published in The Lancet: Diabetes and Endocrinology.

What kind of research was this?

Severe Autoimmune Diabetes largely overlapped with the current Type 1 diagnosis. The person is completely unable to produce insulin and relies on lifelong insulin.

And an estimated 550,000 people have Type 2 but are unaware of it. Management ranges from dietary control or medication through to daily insulin injections.

The scientists found one autoimmune type of diabetes - a condition in which the body produces chemicals that destroy insulin.

Shannon Airport 'remains fully operational' despite snow and poor weather
Ryanair have announced that some 50 flights have been cancelled for tomorrow, along with some from Aer Lingus and global carriers. Gatwick Airport has announced, "Flights are arriving and departing from Gatwick as normal".


Presidential Elections in Venezuela Set for Second Half of May
Falcon declared his candidacy on Tuesday ahead of Thursday's official deadline. He has already launched his election campaign.


Shocking footage of the aftermath of the Dublin Lidl looting is released
Nine men have been arrested in relation to the incident, which saw a JCB collide into the Lidl and drag the roof off the premises. Mr Smew, who is aged 26, is also charged with the possession of a weapon, which was claimed in court to be a sledgehammer.


What did the research involve?

Today, about 425 million people around the world have diabetes. It included 844 people.

Based on these parameters the participants were classified into 5 groups.

At present, around 400 million people globally are living with the disease, making it one of the biggest health issues facing modern medicine.

GADAs are antibodies linked with what is known as late-onset autoimmune diabetes (LADA).

The growing concern of type-2 diabetes needs no introduction - so, identifying a drug that is already in circulation that might help to fight the condition would be a welcome discovery.

Severe Insulin-Deficient Diabetes (SIDD) was made up of relatively young adults with especially poor metabolic control. About 6% of the people in the ANDIS study had SAID.

Initially looked very similar to cluster 1, but the immune system in these patients was not at fault. Identified in 18% of the people in ANDIS. Clusters 1 and 2 had a greater risk of diabetic ketoacidosis and had a higher HbA1c at diagnosis.

Most of the patients (nearly 40 percent) in the cohort belonged to the cluster 5. This cluster had the highest incidence of diabetic retinopathy.

Type 2 is also a lifelong condition, which generally develops later in life.

They believe the more precise groupings - each genetically distinct - will aid diagnosis, help tailor treatments and lead to precision medicines.

In the same way that a patient requiring a transfusion must receive the right blood type, diabetes sub-types need different treatments, the study suggested.

Researchers did not observe between-cluster differences for age- and sex-adjusted coronary event and stroke risk, and no genetic variant was associated with all the clusters.



Other News

Trending Now

Ronda Rousey tweets following events on Monday Night Raw
Monday night, the two will likely confront each other to further a potential match between the two at WrestleMania . After putting Triple H through the table, Rousey was confronted by McMahon who slapped Rousey.

Pauses in Syria suburb unilateral, 'not enough — United Nations official
Russian Federation has ordered a five-hour daily humanitarian pause to allow civilians to exit the region, starting on Tuesday. But not one of the battered region's 400,000 residents had left to board buses provided by the regime by late Wednesday.

Wednesday's Biggest Winners and Losers in the S&P 500
United States 10-year Treasury bond has given a breakout of its recent lows of 120.03 raising concern in equity markets . Investors remain focused on President Donald Trump's threat to impose tariffs on steel and aluminum imports.

RBS says Irish border issue is key in bank's post-Brexit future
Theresa May said it could be achieved via a commitment that the UK's regulatory standards are at least as high as the EU's. Officials working at the Nortern Irish customs will have to follow European Union rules.

Mourinho admits Ibrahimovic likely to leave United in summer
The Sweden striker is now sidelined with a knee injury, having played just seven times in all competitions this season. You see his body, you see how he came back from a big injury, we saw him on the pitch and he looks very sharp.

Turkish army, FSA clear 7 more areas in NW Syria
The Kurdish-led Syrian Democractic Forces alliance said the Turkish raids targeted pro-regime positions, but gave no death toll. A deal to allow the Syrian government to take over much of the control of the area might suit numerous parties involved.

Elton John Storms Off Las Vegas Stage After Fan Irritates Him
Moment before his exit on Thursday night, footage shows the 70-year-old appear to shout "f*** off" repeatedly at one concertgoer. It was during a set at his Las Vegas residency at The Colisseum.

Atlas V rocket scheduled to launch today
The information gathered by this instrument will compromise over 65% of all the data gathered by the satellite. GOES-S will be launched into geostationary orbit, which is at a distance of 35786 km from the Earth.

Virginia slips past Louisville on buzzer-beater
How do you know it's March? I think it is important, but I think just trying to be as sound as you can on both ends. But it's not enough. "We've got to get the ball to the shooters, we've got to make the next pass".

Toys R Us and Maplin collapse into administration
Toys R Us UK has appointed Moorfields Advisory to wind down the company while Maplin has asked PwC to oversee its administration. Administrators PwC said Maplin will deliver outstanding customer orders and gift cards will still be accepted in stores for now.