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giftedviz.com August 20, 2018


Fewer Women with Breast Cancer Will Be Getting Chemotherapy

07 June 2018, 01:02 | Rodolfo Wallace

For some breast cancer patients, the chemo decision may now be easier

Participant Adine Usher met last month with study leader Dr. Joseph Sparano at the Montefiore and Albert Einstein College of Medicine in New York

Other experts said the results confirm what many patients and doctors are already doing. And we have known that also. "We are de-escalating toxic therapy", study co-author Dr. Kathy Albain added.

Very high scores are at increased risk of the cancer spreading, and those patients have benefited a lot by chemotherapy.

But as the AP points out, in recent years, cancer treatment has been evolving and moving away from chemotherapy.

Avoiding chemotherapy may come as a relief to many women who are diagnosed with breast cancer, as the treatment comes with a number of side effects, including nausea, hair loss and anemia.

"Chemotherapy is no Shangri-La", Brawley said.

What will she tell women who under prior guidelines received chemo and all its side effects and didn't need it after all? Importantly, chemotherapy still showed some benefit in women with higher Oncotype recurrence scores, and in some women under the age of 50. "I want to live - period.' I can't say how I would have responded to this study, but when it's your life, you'd rather deal with the frightful effects of chemo for a relatively short amount of time than die".

And that's just a wonderful thing, to look somebody in the eye and say, you have got a great prognosis.

Each year more than 20,000 women in the United Kingdom are diagnosed with hormone-receptor positive, HER2-negative, node-negative breast cancer.

Judy, who lives in Florida had an aggressive form of advanced cancer where her major organs were getting involved and there was no scope for treatment with conventional methods such as a chemotherapy, surgery and radiation therapy.

According to a study conducted on a group of over 10,000 women who contain specific features about their tumors, those with early-stage forms of breast cancer could forego chemotherapy.

A POTENTIAL cure for cancer may have been found in the USA after a woman suffering from an "incurable" breast cancer that had spread to some of her organs was cured of the killer illness.

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"The 9-year rate of distant recurrence in women with a recurrence score of 11 to 25 in our trial was approximately 5%, irrespective of chemotherapy use", the authors write.

Charity Breast Cancer Care said it was a "life-changing breakthrough".

The results are even more impressive because breast cancers, like prostate and ovarian cancers, have relatively few mutations - which makes it much harder for the immune system to differentiate and attack them. Women in the intermediate recurrence score group were randomly assigned to receive either endocrine therapy plus chemotherapy or endocrine therapy alone.

Testing solved a big problem of figuring out who needs chemo, said Dr. Harold Burstein of the Dana-Farber Cancer Institute in Boston.

Using a technique called adoptive cell transfer, scientists removed a tumour from her chest and determined which friendly T cells within it were capable of recognising the harmful cancer cells. The drug was approved in 2014 for melanoma and in 2015 for lung cancer.

This week, a trial showed that men given just months or weeks to live after being diagnosed with prostate cancer are surviving for more than a year thanks to a breakthrough in immunotherapy treatment.

"I don't ever think I'll ever have the feeling that I'm completely out of the woods, but this definitely is exciting and makes me feel good", Mall said. "Women don't have to suffer more than there is necessary to be better".

Sparano acknowledged the trial took a long time but said it was worth the wait.

"There will still be some women that need chemotherapy".

While much more study is needed, researchers say because all cancers have mutations, this approach could potentially be used to treat many different types of cancer.

In an attempt to settle this question, investigators designed a clinical trial that assessed the long-term outcomes in women receiving radiation to their IM-MS lymph nodes compared to a control group that did not.



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