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First Successful Uterus Transplant from Deceased Donor Leads to Healthy Baby
First baby is born using transplanted womb from dead woman
06 December 2018, 01:50 | Rodolfo Wallace
Image The transplant surgery lasted 10.5 hours. File pic
This marks the first time a baby was born from a deceaseddonor uterus and the first uterine transplantation to occur in Latin America. The baby girl was born via caesarean section on December 15, 2017, at 35 weeks of gestation. Doctors also removed the womb, partly so the woman would no longer have to take anti-rejection medicines.
Four months before the transplant, she had in-vitro fertilisation resulting in eight fertilised eggs, which were preserved through freezing. When the researchers wrote the paper describing the case - about seven months after the birth - both mom and the baby girl were healthy.
"She couldn't keep the uterus in another pregnancy", said Dr. Wellington Andraus, who worked on her transplant team.
A woman in Brazil who received a womb transplanted from a dead donor has given birth to a health baby girl, in the first successful case of its kind, doctors reported. In 2011 a team in Turkey was the first to transplant a uterus from a deceased donor, but the procedure did not lead to a live birth.
"The Brazilian group has proven that using deceased donors is a viable option", said the Cleveland Clinic's Dr. Tommaso Falcone.
According to reports, the success of this procedure means that there will be a larger option of donors available for those who have trouble conceiving because of uterine factor infertility.
When a 45-year-old mother of three died in September 2016 from a stroke that caused a brain bleed, doctors identified her as a match for the MRKH patient.
For years researchers have been trying to help women who had been either born without uteruses or lost them for medical reasons to carry their own children.
"It enables use of a much wider potential donor population, applies lower costs and avoids live donors' surgical risks".
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The case involved connecting veins from the donor uterus with the then-32-year-old's recipient's veins, as well as linking arteries, ligaments and vaginal canals.
"There are still lots of things we don't understand about pregnancies, like how embryos implant", said Dr. Cesar Diaz, who co-authored an accompanying commentary in the journal. "Now she comes in to show us the baby and she is so happy". Falcone said the fact that the transplant was successful after the uterus was preserved in ice for almost eight hours demonstrated how resilient the uterus is.
It is estimated that between 10 to 15 percent of couples of reproductive age worldwide are affected by infertility.
"They should also encourage forthcoming procedures to be done and reported in a transparent way by endorsing prospective registration of the procedures and by developing accurate registries".
An estimated one in 500 women have no wombs or abnormal wombs due to hysterectomies, inherited disease, malformation or infection.
Infertility affects one in seven people in Britain, and while some problems can be solved through IVF, most women with womb issues have no alternative but adoption or surrogacy.
The baby is the first to be delivered from a donated uterus from a dead donor.
In this trial, the mother was given standard doses of immune suppression medications for nearly six months, with positive results, before implantation of the embryo was completed.
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